Prolonged Amoxicillin Release Kinetics and Biocompatibility Using Chitosan/pva Blend Membranes In-vitro

The present study emphases on chitosan based drug delivery system prepared by blending it with poly vinyl alcohol to modify the processability of the former and to facilitate multiple drug-loading. Blends prepared by varying the ratios of the polymers in the mixture 70:30, 50:50 and 30:70. Chitosan supports paracellular transport of drugs and as extra cellular matrices for cell culturing hence was selected for the study. Scanning electron microscope revealed that the blends show a good adherence to the monkey kidney cells, and also the distribution of the drug was uniform and well dispersed in the membranes. FTIR analysis confirmed that the blends of polymers occurred by means of hydrogen bonding. The drug release profile on a constant load of 100mg of amoxicillin which showed a prolonged release as expected and the cytotoxicity studies proved that the blends were not toxic to the cells. Hence the system could serve as a potential carrier in drug delivery and tissue engineering applications.